Curriculum Vitae

Jorge Llacer                        Director, EC Engineering Consultants LLC

                                           130 Forest Hill Drive

                                          Los Gatos , CA 95032

                                          Tel. And FAX (408) 356-0332

                                          escalivat@jllacer.com 

                                           and

                                                        Adjunct Professor

                                                        Department of Radiation Oncology

                                                        University of California, 

                                                        Los Angeles, California

                                         

 

 

Education

 

1968     Doctor of Philosophy, Stanford University , Electrical Engineering

            Thesis:  "Detailed mechanism of transmission secondary emission in alkali halides".  Thesis advisors:  Dr. W.K.H. Panofsky, Director, Stanford Linear Accelerator Center and Dr. E.L. Garwin, Head of the Physical Electronics Group, Stanford Linear Accelerator Center.

1963     Master of Science, Stanford University , Electrical Engineering

1961     Bachelor of Arts, Dartmouth College

            Summa Cum Laude, with high distinction in Engineering Science.  Elected to membership in Phi Beta Kappa Society.

 

 

Professional Experience  

May 2003 to present

Adjunct Professor of Radiation Oncology, Department of Radiation Oncology, School of Medicine, University of California, Los Angeles, California

1993 to present

Director, EC Engineering Consultants LLC, a small business dedicated to the solution of inverse problems in Medicine, Astronomy and Industry. Principal Investigator in NCI-SBIR Grant No. CA76808-01, “Optimization of Cancer Radiation Therapy Planning”, research period:  01/01/1998 – 10/30/2001.  Consultant to the Laboratory of Nuclear Medicine, UCLA School of Medicine, 1996-1999,

Participating Guest, Lawrence Berkeley Laboratory, University of California , Berkeley .  Systems Engineering Department, Engineering Division until 1997.

1991 to 1993

Senior Staff Computer Scientist, Lawrence Berkeley Laboratory. Principal Investigator, research on "Application of Statistically Based Algorithms to Emission Tomography," supported by DOE Contract No. DE-AC03-76SF00098 and development of concepts related to image analysis, including feature recognition and extraction, by analytical and neural network methods based on Visual Response Functions.

1989 to 1991

Senior Staff Scientist, Lawrence Berkeley laboratory. Principal Investigator, research on "Algorithms and Processing Architectures for Tomography," NIH grant CA-39501 and "Application of Statistically Based Algorithms to Emission Tomography," supported by DOE Contract No. DE-AC03-76SF00098.

1986 to 1989

Senior Staff Scientist, Lawrence Berkeley laboratory. Principal Investigator, research on "Algorithms and Processing Architectures for Tomography," NIH grant CA-39501.  Deputy Manager in charge of Software Research and Development, Active Control System Software, Keck Telescope Project

         Development of instrumentation for characterization of heavy ion beams used in medical and biological research

1979-1986  

Senior Staff Scientist, Lawrence Berkeley laboratory. Research on image reconstruction methods for high-accuracy and high-sensitivity medical imaging from positron emitters.  Design, construction supervision, testing and applications of instrumentation for medical imaging with radioactive beams and for heavy ion beam characterization

1974-1979

Staff Scientist, Lawrence Berkeley laboratory. Research in fundamental processes in solid-state radiation detectors, amplifying devices and materials.  Management of Soft and Hardware development for Biomedical therapy and research computers.

June 1972 to April 1974

Associate Research Physicist in the Laboratory of Nuclear Medicine and Radiation Biology, U.C.L.A.  Adjunct Associate Professor of Electrical Engineering, U.C.L.A.

Basic and applied research in solid state physics, radiation detectors, and application of nuclear electronics techniques to medical, biological and environmental problems.

September 1969 to May 1972

Associate Engineer, Instrumentation Division, Brookhaven National Laboratory, Upton , New York

Research on semiconductor nuclear radiation detectors, associated electronics systems, and applications to nuclear medicine problems

September 1965 to July 1969

Physical Electronics Group, Stanford Linear Accelerator Center , Stanford , California

During the first three years, Graduate Student working on Ph.D. thesis on secondary emission.  In 1968, appointed Engineering Physicist, continuing research on secondary emission and applications to the detection of relativistic particles.

April 1963 to August 1965

Staff Member, Instrumentation Division, Brookhaven National Laboratory

Research on Semiconductor Surfaces, particularly on silicon radiation detectors.  Design of diverse instruments for physics research.  Design of the first real time, large scale, multiple instrument control by computer in a National Laboratory.

September 1961 to March 1963 (except the summer of 1962)

Research Assistant, Microwave Laboratory, Stanford University

Research on numerical methods for the solution of elliptical partial differential equations arising in the design of high-power klystron electron guns.

Summers, 1961 and 1962

Summer appointments at the Instrumentation Division, Brookhaven National Laboratory

Worked on several design problems with transistor circuits

 

Awards

1990          IEEE Nuclear and Plasma Sciences Society 1990 Annual Merit Award, "for contribution to the development of semiconductor radiation detectors and to the understanding of statistically based image reconstruction algorithms in nuclear medical imaging".

Patents

-     Design Geometry for Silicon Lithium Drifted Radiation Detectors in order to increase maximum reverse bias without breakdown noise.

-          Method for improving ultra high-purity germanium radiation detectors by neutron damaging and subsequent anneal.

         -     Method for optimization of radiation therapy planning, November 1997.

Languages

Spanish and English, excellent.  French, excellent reading, good fluency writing and speaking. German, working knowledge.  Dutch, basic knowledge.

Technical Societies

         -     Chairman, Awards Committee, IEEE Nuclear and Plasma Sciences Society,

-     Assistant Program Chairman for Nuclear Medicine sessions, IEEE Nuclear Science Symposium, San Francisco , 1990

-     Co-organizer of the XI International Conference on Information Processing in Medical Imaging, Berkeley , 1989

-     Appointed member of the Administrative Committee, IEEE Nuclear and Plasma Sciences Society, 1988

-     Program Committee, IEEE Nuclear Science Symposium, 1986-1988

-     Assistant Chairman, Program Committee, 1983 Nuclear Science Symposium

-     Member, Administrative Committee of Nuclear and Plasma Sciences Society, IEEE, 1978-1982

-     Chairman, Nuclear Medical Sciences Committee, IEEE, 1978-1982

Publications

 1.      K.J. Harker and J. Llacer, "Conditions for the Solubility of an Elliptic Difference Equation as an Initial Value Problem," Quar. Appl. Math., 223- 234 (1963).

 2.      J. Llacer, "Study of Surface Effects in Think Lithium Drifted Silicon Radiation Detectors," IEEE Trans. Nucl. Sci., NS-1l, No. 3, 22l-23l (1964).

 3.      J. Llacer, "Geometric Control of Surface Leakage Current and Noise in Lithium Drifted Silicon Radiation Detectors," IEEE Trans. Nucl. Sci., NS-13, No. l, 93-102 (1966) 

 4.      J. Llacer and E.L. Garwin, "Electron-Phonon Interaction in Alkali Halides, I.  The Transport of Secondary Electrons with Energies Between 0.25 and 7.5 eV," J. Appl. Phys., 40, No. 7, 2766-2775 (1969).

 5.      J. Llacer and E.L. Garwin, "Electron-Phonon Interaction in Alkali Halides, II.  Transmission Secondary Emission from Alkali Halides," J. Appl. Phys., 40, No. 7, 2776-2792 (1969).

 6.      J. Llacer and E.L. Garwin, "Statistics of Transmission Secondary Emission from Thin Films of Alkali Halides," J. Appl. Phys., 40, No. 10, 3936-3945 (1969).

 7.      E.L. Garwin and J. Llacer, "Mechanism of Secondary Emission and Single Particle Statistics from Low Density Films of Alkali Halides," J. Appl. Phys., 41, No. 4, 1489-1496 (1970).

 8.      J. Llacer, "Particle Identification at Relativistic Energies by the use of Secondary Emitters," IEEE Trans. Nucl. Sci., NS-17, No. 3, 29-42 (1970).

 9.      J. Llacer, "Planar and Coaxial High-Purity Germanium Detectors," Nucl. Instr. and Meth., 98, 259-268 (1972).

10.     Z.H. Cho and J. Llacer, "Timing with High-Purity Germanium Coaxial Detectors," Nucl. Instr. and Meth., 98, 461-466 (1972).

11.     J. Llacer and H.W. Kraner, "Neutron Damage and Annealing in High-Purity Germanium Radiation Detectors," Nucl. Instr. and Meth., 98, 467-475 (1972).

12.     J. Llacer, "Basic Limitations in the Fabrication of Radiation Detectors by Gamma Compensation of Germanium," IEEE Trans. Nucl. Sci., NS-19, No. 1, 295-315 (1972) 

13.     J. Llacer, "A Large Volume High-Purity Germanium Radiation Detector," Nucl. Instr. and Meth., 104, 249-25l (1972).

14.     H.W. Kraner and J. Llacer, "A Large Area Germanium Detector for Rectilinear Scanning," Radiology, 106,  425 (1973).

15.     J. Llacer, "Ultimate Capabilities of Detectors with High-Energy Resolution in Radioisotope Scanning," IEEE Trans. Nucl. Sci., NS-20, No. 1, 273-281 (1973).

16.     J. Llacer and Z.H. Cho, "Preliminary Study of a Germanium Three-Dimensional Camera for Positron Emitting Radioisotopes," IEEE Trans. Nucl. Sci., NS-20, No. l, 282-293 (1973).

17.     J. Llacer, M.M.K. Watt, M. Schieber, M.R. Carlston and W. Schnepple, "Preliminary Studies of Charge Carrier Transport in Mercuric Iodide Radiation Detectors," IEEE Trans. Nucl. Sci., NS-21, No. 1, 305-314 (1974).

18.     J. Ewins and J. Llacer, "On Increasing the Reliability of Fabrication and Handling of Large High-Purity Germanium Detectors," IEEE Trans. Nucl. Sci., NS-21, No. 1, 371-373 (1974).

19.     J. Llacer and L.S. Graham, "Effect of Detector Energy Resolution on Radioisotope Imaging with Gamma Cameras," IEEE Trans. Nucl. Sci., NS-22, No. 1, 309-330 (1975).

20.     J. Llacer, "Accurate Measurement of Noise Parameters in Ultra-Low Noise Opto-Feedback Spectrometer Systems," Proc. 2nd ISPRA Nuclear Electronics Sym., Stresa , Italy (1975); IEEE Trans. Nucl. Sci., NS-22, No. 5, 2033- 2052 (1975).  LBL-3671.

21.     J. Llacer, "Optimum Filtering in the Presence of Dominant 1/f Noise," Nucl. Instr. and Meth., 130, No. 2, 565-570 (1975).  LBL-4251.

22.     J. Llacer, "Schematic Description of EPA Data Handling Software System," EET-1446 (1976).

23.     J. Llacer, "Semiconductor Detectors in Nuclear Medicine Imaging, "CRC Handbook in Clinical Laboratory Science, 2, Sect. A; Nuclear Medicine, Ch. 9, 211-223, R.P. Spencer, Ed., CRC Press (1976).  LBL-4897 

24.     J. Llacer, E.E. Haller and R.C. Cordi, "Entrance Windows in Germanium Low-Energy X-Ray Detectors," IEEE Trans. Nucl. Sci, NS-24, No. l, 5360 (1977).  LBL-5566.

25.     J. Llacer and D.F. Meier, "Excess Noise in Selected Field-Effect Transistors," IEEE Trans. Nucl. Sci., NS-24, No. 1, 3l7-326 (1977).  LBL-5567.

26.     J. Llacer and D.F. Meier, "Performance of a Time-Variant Filter in the Presence of Dominant l/f Noise," Nucl. Instr. and Meth., 142, 597-599 (1977).  LBL-5585.

27.     J. Llacer, A. Chatterjee and C. Tobias, "End-of-Range Localization During Irradiation with Heavy Ion Beams for Therapy and Research," abstract only, Proc. 2nd Int. Congress-World Federation of Nucl. Med. and Biology (1978). LBL-7541.

28.     J. Llacer, "Theory of Imaging with a Very Limited Number of Projections," IEEE Trans. Nucl. Sci., NS-26, No. 1, 596-602 (1979).  LBL-8137.

29.     J. Llacer, A. Chatterjee, H.C. Jackson, J.C. Lin and M.V. Zunzunegui, "An Imaging Instrument for Positron Emitting Heavy Ion Beam Injection," IEEE Trans. Nucl. Sci., NS-26, No. l, 636-647 (1979).  LBL-8138.

30.     J. Llacer, "Optimum Filter for Determination of the Position of an Arbitrary Waveform in the Presence of Noise," IEEE Trans. Nucl. Sci., NS-28, No. 1, 630-633 (1981).  LBL-11036.

31.     J. Llacer, E.E. Haller, W.L. Hansen, J.T. Walton and E. Batho, "Semiconductor Detectors for Medical  Tomography with High Energy Heavy Ions," IEEE Trans. Nucl. Sci., NS-28, No. 1, 161-166 (1981).  LBL-11037.

32.     A. Chatterjee, E.L. Alpen, J. Llacer, J. Alonso and C.A. Tobias, "High Energy Beams of Radioactive Nuclei and their Biomedical Applications," Int. J. Rad. Oncology, Biology and Physics, 7, 503-507 (1981).

33.     W.R. Holley, C.A. Tobias, J.I. Fabrikant, J. Llacer, W.T. Chu and E.V. Benton, "Computerized Heavy Ion Tomography," Appl. of Optical Instrumentation in Medicine IX, Proc. Soc. Photo-Opt. Eng., 273, 283-293 (1981).

34.     J. Llacer, "Nuclear Medical Imaging," IEEE Spectrum, New York , 33-37 (1981).  LBL-12344.

35.     J. Llacer, "Imaging with Accelerated Heavy Ions in Support of Cancer Diagnosis and Therapy," invited abstract only, Proc. Trans. Amer. Nucl. Soc. 1981 Winter Mtg., San Francisco , CA (1981).  LBL-13123.

36.     J. Llacer, "Tomographic Image Reconstruction by Eigenvector Decomposition:  Its Limitations and Areas of Applicability," IEEE Trans. Med. Imaging, MI-1, No. 1, 36-41 (1982).  LBL-13573.

37.     J. Llacer, H. Spieler and F.S. Goulding, "Theoretical Analysis of the Use of Germanium Detectors for Time-of-Flight Emission Tomography," Proc. Workshop on TOF Tomography, St. Louis , MO (1982).  LBL-14401.

38.     J. Llacer, H. Spieler and F.S. Goulding, "Theoretical Analysis of the Use of Germanium Detectors for Time-of-Flight Emission Tomography," IEEE Computer Society 448, 75-82 (1982).  LBL-14401.

39.     J. Llacer, A. Chatterjee, E.K. Batho and J.A. Poskanzer, "Design Analysis and Performance Evaluation of a Two-Dimensional Camera for Accelerated Positron Emitter Beam Injection by Computer Simulation," IEEE Trans. Nucl. Sci., NS-30, No. 1, 617-625 (1983).  LBL-14450.

40.     J. Llacer, C.A. Tobias and W.R. Holley, "Characterization of Fragments in Heavy Ion Beams with a Simple Semiconductor Detector Telescope," abstract only, pres. Radiation Research Society Mtg., San Antonio , TX (1983).

41.     C.A. Tobias, E.A. Blakely, J. Llacer, W.R. Holley and T. Kaai, "Physical and Biological Studies on Fragmentation of Heavy Ion Beams used for Therapy Research," Proc. 7th Int. Congress of Radiation Research, Amsterdam, Martinus Nijhoff Publ. (1983).

42.     A.C. Thompson, J. Llacer, L.C. Finman, E.B. Hughes, J.N. Otis, S. Wilson and H.D. Zeman, "Computed Tomography using Synchrotron Radiation Instrumentation," Brookhaven National Laboratory (1983).  LBL-16458.

43.     E. Benton, R. Henke, R. Cassou, G.T.Y. Chen, J. Llacer, W.R. Holley, T. Kanai and J.T. Lyman, "Evaluation of CR-39 Nuclear Track Detectors for Clinical Dosimetry and Beam Quality Measurements," Med. Phys., 10, 534 (1983).  Abstract only.

44.     J. Llacer, C.A. Tobias, W.R. Holley and T. Kanai, "On Line Characterization of Heavy-Ion Beams with Semiconductor Detectors," Med. Phys., 11, (3), 266-278 (1984).

45.     J. Llacer, A. Chatterjee, W. Saunders, S. Andreae and H.G. Jackson, "Imaging by Injection of Accelerated Radioactive Particle Beams," IEEE Trans. Med. Imaging, MI-3, No. 2, 80-90 (1984).  LBL-17061.

46.     J. Llacer and J.D. Meng, "Matrix-Based Image Reconstruction Methods for Tomography," IEEE Trans. Nucl. Sci., NS-32, No. 1, 855-864 (1985).  LBL-17781.

47.     J. Llacer, C.A. Tobias and J.J. Almasi, "Low LET Particles in Heavy Ion Beams," pres. Radiation Research Soc. Mtg., Los Angeles , CA (1985).  Abstract only.

48.     W.T. Chu, S.B. Curtis, J. Llacer, M.B. McEvoy, M.A. Nyman, T.B. Benner, R.P. Singh and R. Stradtner, "Wobbler Facility for Biomedical Experiments at BEVALAC," pres. Radiation Research Soc. Mtg., Los Angeles, CA (1985).  Abstract only.

49.     J. Llacer, S. Andreae and E. Veklerov, "Towards a Practical Implementation of the MLE Algorithm for Positron Emission Tomography," IEEE Trans. Nucl. Sci., NS-33, No. 1, 468-477 (1986).  LBL-19668.

50.     J. Llacer, S. Andreae and A. Chatterjee, "On the Applicability of the Maximum Likelihood Estimator Algorithm for Image Recovery in Accelerated Positron Emitter Beam Injection," Proc. SPIE Int. Workshop on Phys. and Eng. of Computerized Multidimensional Imaging and Processing, Newport Beach , CA , 671 (1986).  LBL-21276.

51.     J. Llacer, E. Veklerov and E.J. Hoffman, "On the Convergence of the Maximum Likelihood Estimator Method of Tomographic Image Reconstruction," Proc. SPIE Conf. on Med. Imag., Newport Beach , CA , 767 (1987).  LBL-21800.

52.     J. Llacer and E. Veklerov , "The High Sensitivity of the Maximum Likelihood Estimator Method of Tomographic Image Reconstruction," Proc. Int. Symp. on Computer Assisted Radiology (CAR '87), West Berlin, Germany, Springer Verlag (1987).  LBL-21874.

53.     E. Veklerov and J. Llacer, "Stopping Rule for the MLE Algorithm Based on Statistical Hypothesis Testing," IEEE Trans. Med. Imaging, MI-6, 313-319 (1987).  LBL-22963.

54.     J. Llacer, "Positron Emission Medical Measurements with Accelerated Radioactive Ion Beams," Nucl. Sci. Appl., 3, 111-131 (1987).  LBL-23454.

55.     J. Llacer and E. Veklerov, "The Maximum Likelihood Estimator Method of Image Reconstruction:  Its Fundamental Characteristics and Their Origin," Proc. Int. Conf. on Information Processing in Med. Imaging, Utrecht, The Netherlands, Plenum Pub. Co. (1988).  LBL-22417.

56.     E. Veklerov, J. Llacer,  E.J. Hoffman, "MLE Reconstruction of a Brain Phantom Using a Monte Carlo Transition Matrix and a Statistical Stopping Rule," IEEE Trans. Nucl. Sci., NS-35, No. 1, 603-607 (1988).  LBL-23357.

57.     J. Llacer and E. Veklerov , "The Use of a Stopping Rule in Iterative Image Reconstruction," pres. 1988 American Mathematical Society-IMS-SIAM Joint Conf. Spatial Statistics and Imaging, to be publ. in Conf. Proc. (1989).  LBL-25314.

58.     J. Nunez and J. Llacer, "Maximum Entropy and the Concept of Feasibility in Tomographic Image Reconstruction," Proc. SPIE Medical Imaging III Conf., 1090, 359-373 (1989).  LBL-25451.

 59.     J. Llacer and E. Veklerov , "Feasible Images and Practical Stopping Rules in Iterative Image Reconstruction," IEEE Trans. Med. Imaging, 8, No. 2, 186-193 (1989).  LBL-25775.

60.     J. Llacer, E. Veklerov and J. Nunez, "The Concept of Causality in Image Reconstruction," pres. 1988 NATO Advanced Study Institute, Povoa , Portugal . In Medical Images: Formation, Handling and Evaluation , A. E. Todd-Pokroped and M.A. Viergever, Eds., Series F: Computer and System Sciences, Vol. 98, Springer, pp 361-376, 1992.

61.     J. Llacer, E. Veklerov and J. Nunez, "Statistically Based Image Reconstruction for Emission Tomography," Int. J. Imaging Systems and Tech., 1, 132-148 (1989).  LBL-27329.

62.     J. Nunez and J. Llacer, "Bayesian Image Reconstruction in Astronomy," Astrophysics and Space Science, 171, pp. 341-349, 1990 

63.     J. Nunez and J. Llacer, "A Bayesian Image Reconstruction Algorithm with Entropy as Prior Information," pres. Conf. on Errors, Bias and Uncertainties in Astronomy, Observatoire Astronomique de Strasbourg , France (1989).

64.     J. Llacer, E. Veklerov and J. Nunez, "Stopping Rules, Bayesian Reconstructions and Sieves," pres. 1989 Int. Conf. on Information Processing in Medical Imaging (IPMI89), Berkeley (1989).  To be publ. in Conf. Proc. (1990).  LBL-26499.

65.     J. Llacer, "On the Validity of Hypothesis Testing for Feasibility of Image Reconstructions," IEEE Trans. Med. Imaging, 9, No. 2, 226-230 (1990).  LBL-26632.

66.     J. Llacer, D.A. Landis and N.W. Madden, " High Dynamic Range Discriminator for Measurements with Fragmented Heavy Ions," IEEE Trans. Nucl. Sci., NS-37, No. 2, 457-462 (1990).  LBL-27068 

67.     J. Nunez and J. Llacer, "A Fast Bayesian Reconstruction Algorithm for Emission Tomography with Entropy Prior Converging to Feasible Images," IEEE Trans. Med. Imaging, 9, No. 2, 159-171 (1990).  LBL-27074.

68.     E. Veklerov and J. Llacer, "The Feasibility of Images Reconstructed with the Method of Sieves," IEEE Trans. Nucl. Sci., NS-37, No. 2, 835-841 (1990).  LBL-27088.

69.     J. Llacer, J. Schmidt and C. Tobias, "Characterization of Fragmented Heavy-Ion Beams using a Three-Stage Telescope Detector I:  Detector Configuration and Instrumentation," Med. Phys. 17,(2), pp. 158-162, 1990.  LBL- 27490 .  

70.     J. Llacer, J. Schmidt and C. Tobias, "Characterization of Fragmented Heavy-Ion Beams using a Three-Stage Telescope Detector II:  Measurements of 67--Mev/amu ²⁰Ne Beams," Med. Phys. 17, (2), pp. 151-157, 1990.   LBL-27491.

71.     R.C. Jared, A.A. Arthur, S. Andreae, A.K Biocca, R.W. Cohen, J.M. Fuertes, J. Franck, G. Gabor, J. Llacer, T. Mast, J.D. Meng, T. Merrick, R.H. Minor, J. Nelson, M. Orayani, P. Salz, B. Schaefer and C. Witebsky, "The W.M. Keck Telescope Segmented Primary Mirror Active Control System," SPIE, 1236, in Segmented Mirror Control II (1990).  LBL-27586.

72.     R.W. Cohen, S. Andreae, A.K. Biocca, R.C. Jared, J. Llacer, J.D. Meng, R.H. Minor and M. Orayani, "The W.M. Keck Telescope Segmented Primary Mirror Active Control System Software," SPIE, 1236, in Segmented Mirror Control II (1990).  LBL-27588.

73.     J. Llacer and R.C. Jared (LBL) and J.M. Fuertes (UPC), "Analysis of the W.M. Keck Telescope Primary Mirror Control Loop," SPIE, 1236, in Segmented Mirror Control II (1990).  LBL-27591.  

74.     J.M. Fuertes (UPC), and R.C. Jared and J. Llacer (LBL), "An Emulator for the W.M. Keck 10m Telescope," SPIE, 1236, in Segmented Mirror Control II (1990).  LBL-28585.

75.     J. Llacer, E. Veklerov, D. Nolan, S.T. Grafton, J.C. Mazziotta, R.A. Hawkins, C.K. Ho and E.J. Hoffman, "ROC Study of Maximum Likelihood Estimator Human Brain Image Reconstructions in PET Clinical Practice: a Progress Report.", Conference Record of the 1990 IEEE Nuclear Science Symposium, Vol. 2, pp 1556-1561, 1990.

76.     J. Llacer and A. Bajamonde, "Characteristics of Feasible Images obtained from real PET data by MLE, Bayesian, and sieve methods", Proc. SPIE Digital Image Synthesis and Inverse Optics, Vol.  1351, pp 300-312, 1990.

77.     J. Llacer, "Maximum Likelihood Image Reconstruction for Emission Tomography in Nuclear Medicine", Proc. of the 1990 IEEE Colloquium in South America, W.J. Tompkins, Ed., pp 119-125, 1990.

78.     J. Llacer and J. Nunez, "Iterative Maximum Likelihood Estimator and Bayesian Algorithms for Image Reconstruction in Astronomy", Proc. of Workshop on the Restoration of HST Images and Spectra, Space Telescope Science Institute, pp 52-70, 1990.

79.   S.B. Curtis, W.T.Chu, J. Llacer, T. Renner, A. Rodriguez and T.C.H. Yang, "Model predictions using experimental physical data as input are compared with cell survival obtained in heavy charged particle beams", presented at Rad. Res. Soc. meeting, April 1988.

80.     J. Llacer, D. A. Landis and N. W. Madden, " High Dynamic Range Discriminator for Measurements with Fragmented Heavy Ions", IEEE Trans. Nucl. Sci., Vol. 37, No. 2, pp 457-462, 1990.

81.     D. A. Ortendahl and J. Llacer, Eds., Information Processing in Medical Imaging, Vol. 363 of "Progress in Clinical and Biological Research", Wiley-Liss , New York , 1991.

82.     J. Llacer, E. Veklerov and J. Nunez, "Stopping Rules, Bayesian Reconstructions and Sieves", in Information Processing in Medical Imaging,  Vo. 363, "Progress in Clinical and Biological Research", D.A. Ortgendahl and J. Llacer, Eds., pp 81 - 94, 1991.

83.     K.J. Coakley and J. Llacer, "The use of cross-validation as a stopping rule in Emission Tomography image reconstruction", Medical Imaging V: Image Physics", SPIE Vol. 1443, pp 226-233, 1991.

84.     K.J. Coakley and J. Llacer, "An optimized maximum likelihood approach to Positron Emission Tomography image reconstruction", Conf. Record of the 1991 Nuclear Science Symposium, Vol. 3, pp 2084-2088, 1991.

85.     J. Nunez and J. Llacer, "Maximum Likelihood Estimator and Bayesian reconstruction algorithms with likelihood cross-validation", Proc. of First Annual Conference on Astronomical Data Analysis  Software and Systems, Tucson , Arizona , Nov. 1991

86.     J. Llacer, E. Veklerov and J. Nunez, "Preliminary examination of the use of case specific medical information as "prior" in Bayesian reconstruction", In: Information Processing in Medical Imaging, A.C.F. Colchester and D.J. Hawkes (Eds.), Lecture Notes in Computer Science, Springer, pp. 81 - 93, 1991.

87.     J. Llacer, E. Veklerov, K.J.Coakley, E.J. Hoffman and J. Nunez, "Statistical analysis of Maximum Likelihood Estimator Images of human brain FDG PET studies", IEEE Trans. Medical Imaging, Vol. 12, No. 4, pp 215-231, 1993.

88.     J. Llacer, B.M. ter Haar Romeny and M.A. Viergever, "The use of geometric prior information in Bayesian tomographic image reconstruction: a preliminary report",  Proc. SPIE Mathematical Methods in Medical Imaging, Vol. 1768, pp 82-96, 1992.

89.     J. Llacer, B.M. ter Haar Romeny, L.M.J. Florack and M.A. Viergever, "The representation of medical images by Visual Response Functions", invited paper for IEEE Engineering in Medicine and Biology Magazine, March 1993, pp 40-47.

90.     J. Llacer, E. Veklerov, L.R. Baxter, S.T.Grafton, L.K. Griffeth, R.A. Hawkins, C.K. Hoh, J.C. Mazziotta, E.J. Hoffman, C.E. Metz, "Results of a clinical ROC study comparing Filtered Backprojection and Maximum Likelihood Estimator images in FDG PET studies", Journal Nucl. Medicine, Vol. 34, No. 7, pp 1198-1203, 1993.

91.     J. Llacer, B.M. ter Haar Romeny and M.A. Viergever, "The use of Visual Response Functions in Bayesian Reconstruction", presented at the Conference on Information Processing in Medical Imaging, June 1993.

92.     J.  Nunez and J. Llacer, "A general Bayesian image reconstruction algorithm with entropy prior", Publ. Astron. Soc. Pacific, Vol. 105, pp 1-17, 1993.

93.   W.Y. Sun, T.F. Budinger, J. Llacer and S.E. Derenzo, "Power spectra estimation for an adaptive Wiener filter reconstruction", submitted to the 1993 meeting of the Society of Nuclear Medicine.

94.   J. Llacer and M. R. Howells, "The relationship between image quality and radiation dose in low energy X-ray absorption tomography", Report LBL-34000.

95.   J. Nunez and J. Llacer, "HST Image Reconstruction with variable resolution", in The Restoration of HST Images and Spectra- - II  , Proceedings of a Workshop, Space Telescope Science Institute, Baltimore, Maryland, Nov. 1993.  R.J.Hanisch and R.L. White, eds., pp 123-130, 1994.

96.   J. Nunez and J. Llacer, "Bayesian image reconstruction with variable balancing parameter", Proc. of SPIE 1994 Symposium on Astronomical Telescopes and Instrumentation for the 21st Century", Kona , Hawaii , March 1994.

97.    J. Llacer and J. Nunez, "Ghost Images and Feasibility of Reconstruction with the Richardson-Lucy Algorithm", Proc. of SPIE 1994 Int. Conf. on  Image Reconstruction and Restoration, July 1994.

98.     J. Nunez and J. Llacer, "A Bayesian Algorithm for Image Reconstruction with Variable Hyperparameter", Bayesian Statistics 5:  Proc. of the Fifth Valencia International Meeting. June 5-11 1994 , J. M. Bernardo, et al, eds., Oxford Univ. Press, 1994.

99.     J. Vitria and J. Llacer, "Recovering Surface Brightness and Depth from Focus using the Expectation-Maximization Algorithm", Presented at the VI National Symposium of Shape Recognition and Image Analysis, Cordoba, Spain, April 1995.

100.  J. Llacer, "Inverse radiation treatment planning using the Dynamically Penalized Lieklihood method", Med. Phys. 24 (11), 1751-1764 (1997).

101. J. Nunez and J. Llacer, "Bayesian image reconstruction with space-variant noise suppression",  Astronomy & Astrophysics S.S. ,vol. 131, pags. 167-180 (1998).

102.   J.Llacer, “Bayesian smoothing for iterative inverse radiation treatment planning”, presented at the 1998 AAPM meeting, San Antonio , Texas , August 1998.

103.  T.H.Farquhar, J. Llacer, C.K. Hoh, J.Czernin, S.S. Gambhir, M.A. Seltzer, D.H.S.Silverman, J. Qi, C. Hsu and E.J. Hoffman, “ROC and Localization ROC Analyses of Lesion Detection in Whole-Body FDG PET: Effects of Acquisition Mode, Attenuation Correction and Reconstruction Algorithm”, J Nucl Med 1999; 40:2043-2052.

104.  T.H. Farquhar, J. Llacer, J. Sayre, Y.C. Tai and E.J. Hoffman, “ROC and LROC Analyses of the effects of lesion contrast, size and signal-to-noise radio on detectability in PET images” J Nuc Med 2000; 41:745-754.

105.   J.Llacer, “Global and local maxima in the Dynamically Penalized Likelihood method of inverse therapy planning”, presented at the 1999 AAPM meeting, Nashville , Tennessee , July 1999.

106. J. Llacer, T.D. Solberg, C. Promberger and A. Kuzmany, “The use of the Maximum Likelihood Estimator and the Dynamically Penalized Likelihood methods in inverse radiation therapy planning”, presented at the XIII Int. Conf. on the use of Computers in Radiation Therapy, ICCR’2000.